abstract：:Achieving remote and reversible control of bacterial cell-cell interactions associated with interference with pathological processes in living systems remains a challenge owing to the complexity of the in vivo microenvironment and the lack of regulation systems. We present, for the first time, the development of a ver...

journal_title：Biomaterials

authors： Li W,Dong K,Wang H,Zhang P,Sang Y,Ren J,Qu X

更新日期：2019-10-01 00:00:00

abstract：:Liver fibrosis is a major characteristic of liver disease. When the liver is damaged, quiescent hepatic stellate cells (HSCs) transdifferentiate into proliferative myofibroblastic/activated HSCs, which are the main contributors to liver fibrosis. Hence, a strategy for regulating HSC activation is important in the trea...

journal_title：Biomaterials

authors： Wang S,Kim J,Lee C,Oh D,Han J,Kim TJ,Kim SW,Seo YS,Oh SH,Jung Y

更新日期：2019-10-01 00:00:00

abstract：:The regeneration of large bone defects remains an unsolved clinical problem, which could benefit from recent findings on the biology of skeletal stem and progenitor cells. The elucidation of conditions to specifically control their dynamic and function will likely enable the development of novel treatment strategies. ...

journal_title：Biomaterials

authors： Papageorgiou P,Vallmajo-Martin Q,Kisielow M,Sancho-Puchades A,Kleiner E,Ehrbar M

更新日期：2019-10-01 00:00:00

abstract：:Acute kidney injury (AKI) is associated with high mortality and morbidity with no effective treatment available at present, which greatly escalates the risk of chronic kidney disease. Nanotechnology-based drug delivery for targeting renal tubules offers a new strategy for AKI treatment but remains challenging due to t...

journal_title：Biomaterials

authors： Yu H,Lin T,Chen W,Cao W,Zhang C,Wang T,Ding M,Zhao S,Wei H,Guo H,Zhao X

更新日期：2019-10-01 00:00:00

abstract：:A PCL/hydrogel construct that would mimic the structural organization, biochemistry and anatomy of meniscus was engineered. The compressive (380 ± 40 kPa) and tensile modulus (18.2 ± 0.9 MPa) of the PCL scaffolds were increased significantly when constructs were printed with a shifted design and circumferential strand...

journal_title：Biomaterials

authors： Bahcecioglu G,Bilgen B,Hasirci N,Hasirci V

更新日期：2019-10-01 00:00:00

abstract：:Vaccination is an effective medical intervention for preventing disease. However, without an adjuvant, most subunit vaccines are poorly immunogenic. This work develops a bioinspired nanocomposite hyaluronic acid hydrogel system that incorporates N-trimethyl chitosan nanoparticles (TMC/NPs) that carry a model subunit v...

journal_title：Biomaterials

authors： Korupalli C,Pan WY,Yeh CY,Chen PM,Mi FL,Tsai HW,Chang Y,Wei HJ,Sung HW

更新日期：2019-09-01 00:00:00

abstract：:Combined and targeted therapy have been extensively employed to achieve more effective elimination of tumor tissues. In this study, biocompatible multifunctional lipid-coated calcium phosphate nanoparticles (LCP NPs) were designed and constructed as an efficient targeted delivery system for combined gene/photothermal ...

journal_title：Biomaterials

authors： Tang J,Li B,Howard CB,Mahler SM,Thurecht KJ,Wu Y,Huang L,Xu ZP

更新日期：2019-09-01 00:00:00

abstract：:In mammalian embryos, cortical interneurons travel long distances among complex three-dimensional tissues before integrating into cortical circuits. Several molecular guiding cues involved in this migration process have been identified, but the influence of physical parameters remains poorly understood. In the present...

journal_title：Biomaterials

authors： Leclech C,Renner M,Villard C,Métin C

更新日期：2019-09-01 00:00:00

abstract：:Current advances in skin tissue engineering and wound healing augur well for the development of split or full thickness skin substitutes to recapitulating the native functional skin. These engineered skin substitutes have fared successfully in recent years with exploration of various emerging technologies. As a result...

journal_title：Biomaterials

authors： Chouhan D,Dey N,Bhardwaj N,Mandal BB

更新日期：2019-09-01 00:00:00

abstract：:Acute and chronic wounds affect millions and are associated with billions of dollars in healthcare costs. The use of healing markers, biochemical cues from biocompatible matrices and materials, and their correlation with wound healing has the potential to generate valuable diagnostic, prognostic, and therapeutic infor...

journal_title：Biomaterials

authors： Roussakis E,Ortines RV,Pinsker BL,Mooers CT,Evans CL,Miller LS,Calderón-Colón X

更新日期：2019-08-01 00:00:00

abstract：:Lysosomes, an important organelle of eukaryotic cells, are covered with the cell membrane and contain an array of degradative enzymes. The disrupt in lysosomal functions may lead to the development of severe diseases. In nanotechnology, nanomaterials working mechanism and its biomedical output are highly dependent on ...

journal_title：Biomaterials

authors： Rathore B,Sunwoo K,Jangili P,Kim J,Kim JH,Huang M,Xiong J,Sharma A,Yang Z,Qu J,Kim JS

更新日期：2019-08-01 00:00:00

abstract：:Theranostic biomaterials have been creating great new opportunities in developing precision medicine in cancer treatment. Moreover, there exist up-coming potentials to find a new paradigm change in cancer treatment when theranostic biomaterials can precisely image a biological process at the exact tumor sites. With ai...

journal_title：Biomaterials

authors： Kim H,Kwak G,Kim K,Yoon HY,Kwon IC

更新日期：2019-08-01 00:00:00

abstract：:Mesenchymal stromal/stem cell (MSC)-based therapy is a promising approach for the treatment of heart failure. However, current MSC-delivery methods result in poor donor cell engraftment, limiting the therapeutic efficacy. To address this issue, we introduce here a novel technique, epicardial placement of bi-layered, a...

journal_title：Biomaterials

authors： Kobayashi K,Ichihara Y,Sato N,Umeda N,Fields L,Fukumitsu M,Tago Y,Ito T,Kainuma S,Podaru M,Lewis-McDougall F,Yamahara K,Uppal R,Suzuki K

更新日期：2019-07-01 00:00:00

abstract：:Notorious bacterial biofilms are becoming severe threats to public health worldwide. As the important component in biofilm extracellular polymeric substances (EPS), extracellular DNA (eDNA) has been manifested to connect different EPS components and bacteria together, leading biofilms hard to eliminate. Herein a serie...

journal_title：Biomaterials

authors： Liu Z,Wang F,Ren J,Qu X

更新日期：2019-07-01 00:00:00

abstract：:As synergistic photothermal immunotherapy has developed as one of the most attractive strategies for cancer therapy, it is crucial to design an effective photothermal immunotherapy system to enhance the synergistic anti-tumor effect and reveal the essential role of each treatment. In this study, we designed CpG self-c...

journal_title：Biomaterials

authors： Dong X,Liang J,Yang A,Qian Z,Kong D,Lv F

更新日期：2019-07-01 00:00:00

abstract：:Breast cancer is associated with high mortality due to tumor metastasis. The anti-metastasis efficacy of photochemotherapy is strictly limited by poor targeting capability with respect to circulating tumor cells (CTCs) in blood and lymph. Herein, we decorate the platelet membrane (PM) on a surface of nanoparticles (NP...

journal_title：Biomaterials

authors： Ye H,Wang K,Wang M,Liu R,Song H,Li N,Lu Q,Zhang W,Du Y,Yang W,Zhong L,Wang Y,Yu B,Wang H,Kan Q,Zhang H,Wang Y,He Z,Sun J

更新日期：2019-06-01 00:00:00

abstract：:Reliable single unit neuron recordings from chronically implanted microelectrode arrays (MEAs) are essential tools in the field of neural engineering. However, following implantation, MEAs undergo a foreign body response that functionally isolates them from the brain and reduces the useful longevity of the array. We t...

journal_title：Biomaterials

authors： Cassar IR,Yu C,Sambangi J,Lee CD,Whalen JJ 3rd,Petrossians A,Grill WM

更新日期：2019-06-01 00:00:00

abstract：:The use of biochemical signaling to derive smooth muscle cells (SMCs) from mesenchymal stem cells (MSCs) has been explored, but the induction of a fully functional SMC phenotype remains to be a major challenge. Cell morphology has been shown to regulate MSC differentiation into various lineages, including SMCs. We eng...

journal_title：Biomaterials

authors： Yeh YT,Wei J,Thorossian S,Nguyen K,Hoffman C,Del Álamo JC,Serrano R,Li YJ,Wang KC,Chien S

更新日期：2019-06-01 00:00:00

abstract：:A perfect "off" to "on" switch of the therapeutic function is very important to minimize the phototoxicity of nanoplatforms assisted imaging-guided photodynamic therapy (PDT) of cancer. Current approaches rely on preloaded photosensitizers, where the off/on state of PDT is regulated by the sensitizing light of photose...

journal_title：Biomaterials

authors： Feng Y,Wu Y,Zuo J,Tu L,Que I,Chang Y,Cruz LJ,Chan A,Zhang H

更新日期：2019-05-01 00:00:00

abstract：:Nanoparticle-induced autophagy is crucial for its metabolism, cytotoxicity and therapy potency, but little is known about how the host immune system would respond to it. In this study, we demonstrated that two clinically used superparamagnetic iron oxide nanoparticles (SPIONs) specifically induced macrophage autophagy...

journal_title：Biomaterials

authors： Jin R,Liu L,Zhu W,Li D,Yang L,Duan J,Cai Z,Nie Y,Zhang Y,Gong Q,Song B,Wen L,Anderson JM,Ai H

更新日期：2019-05-01 00:00:00

abstract：:Although photothermal therapy (PTT) and photodynamic therapy (PDT) are widely commended for tumor treatment recently, they still suffer severe challenges due to the non-specificity of photothermal agents (PTAs)/photosensitizers (PSs) and hypoxic tumor microenvironment. Here, an oxygen independent biomimetic nanoplatfo...

journal_title：Biomaterials

authors： Zhang C,Liu WL,Bai XF,Cheng SX,Zhong ZL,Zhang XZ

更新日期：2019-04-01 00:00:00

abstract：:Targeted tumor imaging and efficient specific gene delivery in vivo has been one of the main challenges in gene-based cancer diagnosis and therapy. Herein, we engineered a citric acid-based polymer with intrinsical photoluminescence and gene loading capacity to achieve targeted delivery of siRNA and tumor imaging in v...

journal_title：Biomaterials

authors： Wang M,Guo Y,Xue Y,Niu W,Chen M,Ma PX,Lei B

更新日期：2019-04-01 00:00:00

abstract：:Recent advances in materials development and tissue engineering has resulted in a substantial number of bioinspired materials that recapitulate cardinal features of bone extracellular matrix (ECM) such as dynamic inorganic and organic environment(s), hierarchical organization, and topographical features. Bone mimickin...

journal_title：Biomaterials

authors： Shih YV,Varghese S

更新日期：2019-04-01 00:00:00

abstract：:Organ-on-a-chip platforms serve as cost-efficient testbeds for screening pharmaceutical agents, mimicking natural physiology, and studying disease. In the field of diabetes, the development of an islet-on-a-chip platform would have broad implications in understanding disease pathology and discovering potential therapi...

journal_title：Biomaterials

authors： Jiang K,Chaimov D,Patel SN,Liang JP,Wiggins SC,Samojlik MM,Rubiano A,Simmons CS,Stabler CL

更新日期：2019-04-01 00:00:00

abstract：:Hydrogels are commonly used as artificial extracellular matrices for 3D cell culture and for tissue engineering. Viscoelastic hydrogels with tunable stress relaxation have recently been developed, and stress relaxation in the hydrogels has been found to play a key role in regulating cell behaviors such as differentiat...

journal_title：Biomaterials

authors： Nam S,Stowers R,Lou J,Xia Y,Chaudhuri O

更新日期：2019-04-01 00:00:00

abstract：:Cell delivery in cell therapy is typically challenged by the low cell survival rate and immunological rejection during cells injection and circulation. Encapsulation of cells with semipermeable hydrogels or membranes can improve cell viability by resisting high shear force and inhibit immune response with the physical...

journal_title：Biomaterials

authors： Yang J,Yang Y,Kawazoe N,Chen G

更新日期：2019-03-01 00:00:00

abstract：:Neural tissue engineering holds great promise in repairing damaged nerve tissues. However, despite the promising results in regenerating the injured nervous system, tissue engineering approaches are still insufficient to result in full functional recovery in severe nerve damages. Majority of these approaches only focu...

journal_title：Biomaterials

authors： Chooi WH,Chew SY

更新日期：2019-03-01 00:00:00

abstract：:Targeted drug delivery with precisely controlled drug release and activation is highly demanding and challenging for tumor precision therapy. Herein, a biomimetic cascade nanoreactor (designated as Mem@GOx@ZIF-8@BDOX) is constructed for tumor targeted starvation therapy-amplified chemotherapy by assembling tumor cell ...

journal_title：Biomaterials

authors： Cheng H,Jiang XY,Zheng RR,Zuo SJ,Zhao LP,Fan GL,Xie BR,Yu XY,Li SY,Zhang XZ

更新日期：2019-03-01 00:00:00

abstract：:Retinal ischemia is a major cause of vision loss and impairment and a common underlying mechanism associated with diseases such as glaucoma, diabetic retinopathy, and central retinal artery occlusion. The regenerative capacity of the diseased human retina is limited. Our previous studies have shown the neuroprotective...

journal_title：Biomaterials

authors： Mathew B,Ravindran S,Liu X,Torres L,Chennakesavalu M,Huang CC,Feng L,Zelka R,Lopez J,Sharma M,Roth S

更新日期：2019-03-01 00:00:00

abstract：:Mesenchymal stem cells (MSCs) have gained increasing attention as a potential approach for the treatment of bone injuries due to their multi-lineage differentiation potential and also their ability to recognize and home to damaged tissue sites, secreting bioactive factors that can modulate the immune system and enhanc...

journal_title：Biomaterials

authors： Bunpetch V,Zhang ZY,Zhang X,Han S,Zongyou P,Wu H,Hong-Wei O

更新日期：2019-03-01 00:00:00

abstract：:Human induced pluripotent stem cell (hiPSC) derived angiogenesis models present a unique opportunity for patient-specific platforms to study the complex process of angiogenesis and the endothelial cell response to biomaterial and biophysical changes in a defined microenvironment. We present a refined method for differ...

journal_title：Biomaterials

authors： Natividad-Diaz SL,Browne S,Jha AK,Ma Z,Hossainy S,Kurokawa YK,George SC,Healy KE

更新日期：2019-02-01 00:00:00

abstract：:While polymeric nano-formulations for RNAi therapeutics hold great promise for molecularly-targeted, personalized medicine, they possess significant systemic delivery challenges including rapid clearance from circulation and the potential for carrier-associated toxicity due to cationic polymer or lipid components. Her...

journal_title：Biomaterials

authors： Jackson MA,Bedingfield SK,Yu F,Stokan ME,Miles RE,Curvino EJ,Hoogenboezem EN,Bonami RH,Patel SS,Kendall PL,Giorgio TD,Duvall CL

更新日期：2019-02-01 00:00:00

abstract：:Stroke, traumatic brain injuries, and other similar conditions often lead to significant loss of functional brain tissue and associated disruption of neuronal signaling. A common strategy for replacing lost neurons is the injection of dissociated neural stem cells or differentiated neurons. However, this method is unl...

journal_title：Biomaterials

authors： Liaudanskaya V,Jgamadze D,Berk AN,Bischoff DJ,Gu BJ,Hawks-Mayer H,Whalen MJ,Chen HI,Kaplan DL

更新日期：2019-02-01 00:00:00

abstract：:Aberrant regulation of angiogenesis supply sufficient oxygen and nutrients to exacerbate tumor progression and metastasis. Taking this hallmark of cancer into account, reported here is a self-monitoring and triple-collaborative therapy system by auto-fluorescent polymer nanotheranostics which could be concurrently aga...

journal_title：Biomaterials

authors： Shao L,Li Q,Zhao C,Lu J,Li X,Chen L,Deng X,Ge G,Wu Y

更新日期：2019-02-01 00:00:00

abstract：:Endotoxemia is a severe pathophysiology induced by bacterial endotoxin (also known as lipopolysaccharide, LPS), causing high mortality in clinic due to the life-threatening syndromes, such as sepsis, shock, and multiple organ dysfunction. Removing or neutralizing endotoxin from the circulatory system has been proven t...

journal_title：Biomaterials

authors： Shen S,Han F,Yuan A,Wu L,Cao J,Qian J,Qi X,Yan Y,Ge Y

更新日期：2019-01-01 00:00:00

abstract：:Cancer stem cells (CSCs) play pivotal roles in cancer metastasis, and strategies targeting cancer stemness may greatly reduce cancer metastasis and improve patients' survival. The canonical Wnt/β-catenin pathway plays critical roles in CSC generation and maintenance as well as in normal stem cells. Non-specifically su...

journal_title：Biomaterials

authors： Li Y,Xiao Y,Lin HP,Reichel D,Bae Y,Lee EY,Jiang Y,Huang X,Yang C,Wang Z

更新日期：2019-01-01 00:00:00

abstract：:Microvessels of the blood-brain barrier (BBB) regulate transport into the brain. The highly specialized brain microvascular endothelial cells, a major component of the BBB, express tight junctions and efflux transporters which regulate paracellular and transcellular permeability. However, most existing models of BBB m...

journal_title：Biomaterials

authors： Linville RM,DeStefano JG,Sklar MB,Xu Z,Farrell AM,Bogorad MI,Chu C,Walczak P,Cheng L,Mahairaki V,Whartenby KA,Calabresi PA,Searson PC

更新日期：2019-01-01 00:00:00

abstract：:Phototherapy has drawn increasing attention including the use of nanocarriers with high drug loading capacity and delivery efficacy for target-specific therapy. We have made use of naturally-occurring halloysite nanotubes (HNTs) to build a biomimetic nanocarrier platform for target-specific delivery of phototherapeuti...

journal_title：Biomaterials

authors： Li LY,Zhou YM,Gao RY,Liu XC,Du HH,Zhang JL,Ai XC,Zhang JP,Fu LM,Skibsted LH

更新日期：2019-01-01 00:00:00

abstract：:Peritoneal invasion through the mesothelial cell layer is a hallmark of ovarian cancer metastasis. Using tissue engineering technologies, we recreated an ovarian tumor microenvironment replicating this aspect of disease progression. Ovarian cancer cell-laden hydrogels were combined with mesothelial cell-layered melt e...

journal_title：Biomaterials

authors： Loessner D,Rockstroh A,Shokoohmand A,Holzapfel BM,Wagner F,Baldwin J,Boxberg M,Schmalfeldt B,Lengyel E,Clements JA,Hutmacher DW

更新日期：2019-01-01 00:00:00

abstract：:Silica nanoparticles are widely used platform materials for the immobilization of proteins to realize applications in biomedicine and biotechnology. We here report on the use of a highly delicate protein for the systematic evaluation of routes for the surface modification of multifunctional silica nanoparticles. To in...

journal_title：Biomaterials

authors： Leidner A,Bauer J,Ebrahimi Khonachah M,Takamiya M,Strähle U,Dickmeis T,Rabe KS,Niemeyer CM

更新日期：2019-01-01 00:00:00